Introduction

The development of effective probiotics to enhance immune function is an area of growing interest in both scientific research and practical application. This journal entry details the innovative approach taken to create a composite probiotic product aimed at improving immune responses.

Technical Field

This invention pertains to the field of biotechnology and probiotics, specifically focusing on the development and application of a composite probiotic designed to boost the immune system. The composite probiotic consists of specific strains of Bifidobacterium and Lactobacillus known for their health benefits.

Background

Probiotics are live microorganisms that provide health benefits when consumed in adequate amounts. They are particularly known for their role in maintaining gut health and enhancing immune responses. The gut microbiota plays a crucial role in immune system function, influencing both local and systemic immunity. However, the effectiveness of probiotics can be significantly enhanced by combining different strains that synergistically boost immune functions.

Invention Summary

The primary objective of this invention is to provide a composite probiotic that enhances the immune system more effectively than individual strains. The composite probiotic comprises:
1. Bifidobacterium animalis subsp. lactis BLa80 (CGMCC No. 15410)
2. Lactobacillus rhamnosus LRa05 (CGMCC No. 1.12734)
3. Lactobacillus acidophilus LA05 (CGMCC No. 23546)

These strains are combined to create a synergistic effect, enhancing their individual immune-boosting properties. The combination has shown superior efficacy in improving various immune parameters compared to any single strain alone.

Detailed Description

Probiotic Composition

The probiotic composition includes specific ratios of BLa80, LRa05, and LA05 strains. The optimal ratio for these strains’ ranges from 1:1:1 to 5:5:5 in terms of live bacterial count. This balanced proportion ensures maximum synergistic effect, promoting significant improvements in immune function.

Mechanism of Action

The composite probiotic enhances immune function through several mechanisms:
1. Increased Antioxidant Levels: The combination significantly elevates liver antioxidant factors, which are crucial for reducing oxidative stress and enhancing overall immune function.

2. Reduced Inflammatory Markers: The probiotic mix lowers serum levels of pro-inflammatory cytokines, contributing to a balanced immune response.

3. Enhanced Immunoglobulin Production: There is a notable increase in serum immunoglobulin levels, including IgG and IgA, which play vital roles in systemic and mucosal immunity, respectively.

4. Upregulation of α-Defensins: The probiotics boost the expression of α-defensins in the small intestine, which are essential for maintaining gut barrier integrity and modulating microbial populations.

Applications

The composite probiotic can be utilized in various forms, including dietary supplements, functional foods, and pharmaceutical preparations, to enhance immune function. It is particularly beneficial for individuals with weakened immune systems, chronic inflammation, or those seeking to maintain optimal health.

Conclusion

The development of this composite probiotic represents a significant advancement in the field of immune-enhancing probiotics. By leveraging the synergistic effects of BLa80, LRa05, and LA05 strains, this innovative product offers a promising solution for boosting immune function and promoting overall health.