When the 49ers host the Chargers in Santa Clara in the penultimate game of NFL Week 10 on "Sunday Night Football" (8:20 p.m. ET, NBC), they will be looking to work their way above .500 for the stretch run. San Francisco (4-4) in the NFC and Los Angeles (5-3) in the AFC are both second-place teams in Junior Bridgeman Jersey the Wests (behind Seattle and Kansas City) and also would be the No. 7 wild-card playoff seeds in each conference.The 49ers are feeling good again with Jimmy Garoppolo operating an offense with a high running floor and a greater pa sing ceiling. The Chargers have needed to be more one-dimensional with Justin Herbert with not much of a running game. Herbert also hasn't seen the same level of pa s protection and isn't having the same kind of succe s without top wide receivers Keenan Allen (hamstring) and Mike Williams (ankle).Here's everything to know about betting on 49ers vs. Chargers in Week Christian Wood Jersey 10, including updated odds, trends and our prediction for "Sunday Night Football."NFL WEEK 10 PICKS: | Spread: 49ers by 7Over/under: 45.5Moneyline:Chargers +240, 49ers -300The 49ers get the home-field post-bye bump with a strong advantage vs. the road-weary Chargers, who might be looking ahead to next Sunday night's home game vs. the Chiefs.()49ers vs. Chargers all-time seriesThe Chargers lead the limited series 8-7. They have won five in a row going back 20 years to Nov. 2002. Most notably, the teams met in Super Bowl 29 in Miami after the 1994 season. The 49ers romped in that game, 49-26, with future Hall of Famer Steve Young being named MVP.Three trends to know59 percent of spread bettors are siding with the 49ers to Ersan Ilyasova Jersey win by more than a touchdown and extra point.57 percent of total bettors are liking the game to go over based on some of the offensive stars from both teams.The 49ers are 4-4 against the spread this season with only 3 games going over. The Chargers are 5-3 against the spread with 4 games going over.Three things to watchThe 49ers after the byeSan Francisco will be fully loaded offensively and have some better health defensively. They have already swept NFC's Los Angeles team in their own division and are looking to own all of Southern California in the NFL. The 49ers also will be motivated to keep playing well and Bob Dandridge Jersey winning with Seahawks not relenting.Austin Ekeler vs. Christian McCaffreyEkeler is having another monster season. He's leading the league in combined rushing and receiving TDs again with 10 after 8 games after an NFL-best 20 in 2021. He's also on pace for 128 receptions and 1,717 yards from scrimmage. Those are old-school CMC-like numbers. McCaffrey will try to take advantage of the matchup to show he's still the OG CMC.Only one BosaNick Bosa, the 49ers' premier edge rusher, won't have help from injured Samson Ebukam and Arik Armstead up front, but rookie Drake Jackson can be disruptive vs. Herbert to help. The Chargers are hurting at the offensive tackles.Nick's brother Joey is on IR for the Chargers. The team also will be without edge rusher Chris Rumph, putting a Marvin Williams Jersey lot on Khalil Mack against a strong offensive line anchored by Trent Williams.Stats that matter86.6 and 145.5. The first number is how many average rushing yards per game the 49ers give up, the No. 1 run defense in the NFL. The second is how many average rushing yards per game the Chargers give up, No. 29 in the league. That's strength on weakne s twice for San Francisco.The 49ers' offense will turn the corner to unstoppable with McCaffrey, Deebo Samuel, George Kittle, Brandon Aiyuk, Kyle Juszczyk and others. The Chargers don't have nearly the same amount of weapons to help Ekeler and Herbert facing the much tougher defense.49ers 30, Chargers 20