Yes, some flights from the U.S. to Ghana may fly over or through the Middle East, though it's not the only route. While direct flights are possible, many routes involve layovers in Europe or the Middle East. For example, Qatar Airways flies to Accra via Doha, Qatar. The most popular route from the U.S. to Accra is from JFK to Kotoka International Airport, and some flights on that route may pass over the Middle East, but it's not a guarantee according to Booking.com.